6-巯基嘌呤及其金属配合物对大鼠的抗白血病活性（邓宁腹水瘤）
Anti leukemia activity (Dunning ascitic) of 6-mercaptopurine and its metallo complexes in rats.
作者信息
Skinner S M, Swatzell J M, Lewis R W
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jan;19(1):165-8.
PMID:625586
Abstract
Six-mercaptopurine and its Pt, Pd and Bi complexes were used at various dosage levels to treat Dunning ascitic leukemia in rats. Significant anticarcinogenic activity was found in all compounds with toxicity apparent at the highest dosage level of all but the platinum compound.
摘要
使用不同剂量水平的6-巯基嘌呤及其铂、钯和铋配合物来治疗大鼠的邓宁腹水癌。在所有化合物中均发现了显著的抗癌活性，除铂化合物外，所有化合物在最高剂量水平时均表现出毒性。
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