单独使用以及与9-β-D-阿拉伯呋喃糖基腺嘌呤联合使用赤藓红-9-(2-羟基-3-壬基)腺嘌呤治疗小鼠全身性疱疹病毒感染。
Erythro-9-(2-hydroxy-3-nonyl) Adenine alone and in combination with 9-beta-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice.
作者信息
Shannon W M, Arnett G, Schabel F M, North T W, Cohen S S
出版信息
Antimicrob Agents Chemother. 1980 Oct;18(4):598-603. doi: 10.1128/AAC.18.4.598.
Abstract
Although the antiviral activity of erythro-9-(2-hydroxy-3-nonyl)adenine, a potent adenosine deaminase inhibitor, against herpes simplex virus type 1 in cell culture was readily confirmed, the compound was found to be totally ineffective in the treatment of experimentally induced systemic herpes simplex virus type 1 infections in Swiss mice. Data were obtained, however, which clearly indicated that the antiviral potency of 9-beta-D-arabinofuranosyladenine in vivo could be enhanced by the co-administration of low, nontoxic doses of erythro-9-(2-hydroxy-3-nonyl)adenine.
摘要
尽管强效腺苷脱氨酶抑制剂9-（2-羟基-3-壬基）腺嘌呤（erythro-9-(2-hydroxy-3-nonyl)adenine）在细胞培养中对1型单纯疱疹病毒的抗病毒活性很容易得到证实，但发现该化合物在治疗瑞士小鼠实验性诱导的全身性1型单纯疱疹病毒感染中完全无效。然而，获得的数据清楚地表明，通过联合给予低剂量、无毒的9-（2-羟基-3-壬基）腺嘌呤，9-β-D-阿拉伯呋喃糖基腺嘌呤（9-beta-D-arabinofuranosyladenine）在体内的抗病毒效力可以得到增强。
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