前列腺素对非特异性刺激的人淋巴细胞的影响。
The influence of prostaglandins on non-specifically stimulated human lymphocytes.
作者信息
Giełdanowski J
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(3):459-63.
The influence of E2 and PGF2 alpha-prostaglandins on the level of cAMP in non-stimulated and stimulated by lectins lymphocytes has been studied. PGE2 increased clearly the level of intracellular cAMP but did not increase the number of blastic cells in the culture. PGF2 alpha did not change any of these factors. Prostaglandins (E2 and F2 alpha) did not influence the level of cAMP in lymphocytes affected previously by lectins (PHA and Con A), except Con A+PGF2 alpha scheme. PGE2 (and partly PGF2 alpha and lectins are supposed to act competitively in relation to the same receptor of lymphocyte cells.
研究了E2和PGF2α-前列腺素对未受刺激及受凝集素刺激的淋巴细胞中cAMP水平的影响。PGE2明显提高了细胞内cAMP水平，但未增加培养物中母细胞的数量。PGF2α对这些因素均无影响。前列腺素（E2和F2α）对先前受凝集素（PHA和Con A）作用的淋巴细胞中的cAMP水平无影响，但Con A + PGF2α组合除外。PGE2（部分PGF2α也是如此）和凝集素被认为在淋巴细胞的同一受体上存在竞争性作用。
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