Lack of effect of exogenous prostaglandins on Fc receptor expression of mouse splenocytes.

Previous work has shown that Prostaglandin E1 (PGE1) and other cyclic AMP elevating agents increase the expression of Fc receptors for IgG (FcR) on the murine pre-B cell lymphoma ABE-8 (Burchiel and Warner, 1980). We have investigated here the effect of Prostaglandins E1, E2, F1alpha, F2alpha on FcR expression of normal mouse lymphocytes. FcR were detected by an indirect fluorescent technique on B lymphocytes. The results show that Prostaglandins in culture did not induced any significant change of FcR + lymphocytes. The results are discussed in terms of the role of FcR in the ontogeny and functions of B lymphocytes.