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胰岛素可使甲状旁腺激素刺激培养的肾细胞产生1,25 - 二羟维生素D3 。

Insulin permits parathyroid hormone stimulation of 1,25-dihydroxyvitamin D3 production in cultured kidney cells.

作者信息

Henry H L

出版信息

Endocrinology. 1981 Feb;108(2):733-5. doi: 10.1210/endo-108-2-733.

DOI:10.1210/endo-108-2-733
PMID:6256162
Abstract

Primary cultures of chick kidney cells in serum free medium respond to PTH with increased production of 1,25(OH)2D3 only when exposed to insulin. The response of 1,25(OH)2D3 is maximal at 5 ng bPTH (1-34) per ml and decreases at higher hormone concentrations. Increased 1,25(OH)2D3 synthesis is not evident after 30 minutes exposure to bPTH and is maximal at 4-6 hours of treatment. Insulin does not increase the cyclic AMP response to PTH suggesting that whatever permissive role it is playing occurs beyond the generation of cyclic AMP.

摘要

鸡肾细胞在无血清培养基中的原代培养物，只有在暴露于胰岛素时，才会对甲状旁腺激素（PTH）产生反应，使1,25-二羟维生素D3（1,25(OH)2D3）的产量增加。1,25(OH)2D3的反应在每毫升5纳克的人甲状旁腺激素（1-34）（bPTH (1-34)）时达到最大值，在更高的激素浓度下会降低。暴露于bPTH 30分钟后，1,25(OH)2D3合成增加不明显，在处理4至6小时时达到最大值。胰岛素不会增加对PTH的环磷酸腺苷（cAMP）反应，这表明无论它发挥何种允许作用，都发生在cAMP生成之后。

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