催乳素而非生长激素能刺激雏鸡肾脏制剂在体外产生1,25 - 二羟维生素D3 。

Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro.

作者信息

Bikle D D, Spencer E M, Burke W H, Rost C R

出版信息

Endocrinology. 1980 Jul;107(1):81-4. doi: 10.1210/endo-107-1-81.

Abstract

We studied the effect of PRL from two species (bovine and turkey) and GH from two species (bovine and turkey) on 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production by two whole cell preparations from vitamin D-deficient chick kidneys (slices and tubules). We observed that 8 ng/ml turkey PRL stimulated 1,25(OH)2D3 production by renal tubules and slices. Ovine PRL had a similar effect on 1,25(OH)2D3 production but at higher concentrations. In contrast, neither bovine GH nor turkey GH stimulated 1,25(OH)2D3 production appreciably at doses up to 1000 ng/ml. The effect of PRL on 1,25(OH)2D3 production by renal tubules required a 3-h preincubation, although its effect on 1,25(OH)2D3 production by renal slices was immediate. We conclude that PRL, but not GH, directly stimulates 1,25(OH)2D3 production by the chick kidney.

摘要

我们研究了两种物种（牛和火鸡）的催乳素（PRL）以及两种物种（牛和火鸡）的生长激素（GH）对来自维生素D缺乏雏鸡肾脏的两种全细胞制剂（切片和肾小管）生成1,25 - 二羟基维生素D3 [1,25(OH)2D3]的影响。我们观察到8 ng/ml的火鸡PRL可刺激肾小管和切片生成1,25(OH)2D3。绵羊PRL对1,25(OH)2D3的生成有类似作用，但所需浓度更高。相比之下，在高达1000 ng/ml的剂量下，牛GH和火鸡GH均未明显刺激1,25(OH)2D3的生成。PRL对肾小管生成1,25(OH)2D3的影响需要预孵育3小时，而其对肾切片生成1,25(OH)2D3的影响是即时的。我们得出结论，PRL而非GH可直接刺激雏鸡肾脏生成1,25(OH)2D3。