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关于妇科癌症中妊娠区蛋白(PZ)的出现情况。

On the occurrence of the pregnancy zone protein (PZ) in gynecological cancer.

作者信息

Damber M G, von Schoultz B, Stigbrand T

出版信息

Arch Gynakol. 1976 Sep 17;221(2):97-101. doi: 10.1007/BF00667139.

DOI:10.1007/BF00667139
PMID:62562
Abstract

Reports have been made that the pregnancy zone protein (PZ) is found in increased amounts in sera of patients with malignant disease. The serum concentration of PZ was measured by a radioimmunoassay in 83 women with the diagnosis of gynaecological cancer or other malignancies. Values did not significantly differ from values previously recorded in apparently healthy women. There was no support for previous data of increased levels of PZ in cancer patients, when the age-dependent increase of this serum factor was considered.

摘要

已有报告称,在恶性疾病患者的血清中发现妊娠区蛋白(PZ)含量增加。通过放射免疫分析法对83名被诊断为妇科癌症或其他恶性肿瘤的女性的血清PZ浓度进行了测量。这些值与先前在明显健康的女性中记录的值没有显著差异。当考虑到这种血清因子随年龄的增加时,没有证据支持先前关于癌症患者中PZ水平升高的数据。

相似文献

1
On the occurrence of the pregnancy zone protein (PZ) in gynecological cancer.关于妇科癌症中妊娠区蛋白(PZ)的出现情况。
Arch Gynakol. 1976 Sep 17;221(2):97-101. doi: 10.1007/BF00667139.
2
[Serum concentration of the pregnancy-associated alpha2 glycoprotein (alpha2-PAG, protein of the "pregnancy zone", PZ) in malignant gynecologic diseases].[恶性妇科疾病中妊娠相关α2糖蛋白(α2-PAG,“妊娠区”蛋白,PZ)的血清浓度]
Zentralbl Gynakol. 1979;101(7):457-63.
3
Letter: Pregnancy-associated alpha2-glycoprotein and cancer.信函:妊娠相关α2-糖蛋白与癌症
Lancet. 1976 May 29;1(7970):1182. doi: 10.1016/s0140-6736(76)91567-1.
4
Induction of the "pregnancy zone" protein by conjugated oestrogens.结合雌激素对“妊娠区”蛋白的诱导作用。
Acta Obstet Gynecol Scand. 1976;55(4):321-3. doi: 10.3109/00016347609158506.
5
Letter: Pregnancy-associated alpha2-glycoprotein and cancer.信函:妊娠相关α2糖蛋白与癌症
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6
[Pregnancy associated alpha2-glycoprotein (alpha2-PAG) in the serum of patients with gynecologic carcinomas].妇科癌症患者血清中的妊娠相关α2-糖蛋白(α2-PAG)
Onkologie. 1978 Oct;1(5):180-3. doi: 10.1159/000213947.
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Basic levels of the immuno suppressive serum protein PZ in women-influence of age, parity, gonadotrophins and estrogens.女性免疫抑制血清蛋白PZ的基础水平——年龄、产次、促性腺激素和雌激素的影响
Acta Obstet Gynecol Scand. 1977;56(2):95-9. doi: 10.3109/00016347709158348.
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Immunochemical investigations on the problem of the pregnancy zone protein. XII. Serum concentrations of pregnancy-associated alpha-2-glycoprotein in diabetic pregnancy.关于妊娠区蛋白问题的免疫化学研究。十二、糖尿病妊娠中妊娠相关α-2-糖蛋白的血清浓度。
Arch Gynecol. 1980;229(4):271-8. doi: 10.1007/BF02108578.
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Pregnancy-associated alpha2-glycoprotein.妊娠相关α2-糖蛋白
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Pregnancy zone protein: a re-evaluation of serum levels in healthy women and in women suffering from breast cancer or trophoblastic disease.妊娠区带蛋白:对健康女性以及患有乳腺癌或滋养层疾病女性血清水平的重新评估。
Scand J Clin Lab Invest. 1990 Sep;50(5):479-85. doi: 10.1080/00365519009089162.

引用本文的文献

1
The pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG). A tumour marker?妊娠相关α2-糖蛋白(α2-PAG)。一种肿瘤标志物?
Klin Wochenschr. 1981 Feb 16;59(4):149-55. doi: 10.1007/BF01477474.
2
Purification of an onco-fetal antigen from mammary carcinoma cells.从乳腺癌细胞中纯化一种癌胚抗原。
J Cancer Res Clin Oncol. 1985;110(3):252-4. doi: 10.1007/BF00399285.

本文引用的文献

1
A SERUM PROTEIN PRESENT IN PREGNANT WOMEN.孕妇体内存在的一种血清蛋白。
Nature. 1963 Nov 30;200:892. doi: 10.1038/200892a0.
2
The isolation and partial characterisation of a new alpha-macroglobulin from human pregnancy serum.从人妊娠血清中分离并部分鉴定一种新的α-巨球蛋白。
FEBS Lett. 1972 Jul 1;23(3):298-302. doi: 10.1016/0014-5793(72)80301-6.
3
Production of pregnancy zone protein by contraceptive steroids.避孕类固醇对妊娠区蛋白的产生。
Pa Med. 1967 Jul;70(7):43-4.
4
"Pregnancy protein" in polyacrylamide gradient-gel electrophoresis.聚丙烯酰胺梯度凝胶电泳中的“妊娠蛋白”
Aust J Exp Biol Med Sci. 1969 Oct;47(5):637-41. doi: 10.1038/icb.1969.158.
5
[Detection and characterization of pregnancy proteins in the human placenta and their quantitative immunochemical determination in sera from pregnant women].[人胎盘中妊娠蛋白的检测与特性及其在孕妇血清中的定量免疫化学测定]
Arch Gynakol. 1971 Oct 28;210(4):440-57. doi: 10.1007/BF01628222.
6
[Characterization of pregnancy-associated glycoproteins as acute phase proteins. Their demonstration in serums of patients with neoplasms and other diseases].[妊娠相关糖蛋白作为急性期蛋白的特性。它们在肿瘤患者和其他疾病患者血清中的显示]
Arch Gynakol. 1972;213(1):54-72. doi: 10.1007/BF00668113.
7
[Immunochemical investigations on the protein of the "pregnancy zone". IX. Isolation of the pregnancy zone protein by immunoadsorption (author's transl)].“妊娠区”蛋白质的免疫化学研究。IX. 通过免疫吸附分离妊娠区蛋白质(作者译)
Arch Gynakol. 1974;217(4):415-26. doi: 10.1007/BF00668029.
8
Characterization of the "pregnancy zone protein" in relation to other alpha 2-globulins of pregnancy.“妊娠区蛋白”与妊娠其他α2球蛋白的特征分析。
Biochim Biophys Acta. 1974 Aug 8;359(2):303-10. doi: 10.1016/0005-2795(74)90229-3.
9
A quantitative study of the pregnancy zone protein in the sera of pregnant and puerperal women.孕妇和产妇血清中妊娠区蛋白的定量研究。
Am J Obstet Gynecol. 1974 Jul 15;119(6):792-7. doi: 10.1016/0002-9378(74)90092-1.
10
Inhibition of PHA-induced lymphocyte stimulation by the pregnancy zone protein.妊娠区蛋白对PHA诱导的淋巴细胞刺激的抑制作用。
FEBS Lett. 1973 Dec 15;38(1):23-6. doi: 10.1016/0014-5793(73)80503-4.