Göser R, Jaschonek K, Kindler D, Keller E, Schindler A E
Gynecol Obstet Invest. 1980;11(5):274-85. doi: 10.1159/000299847.
Plasma cAMP was determined using the method of Tovey et al. in normal pregnant women with a mean concentration of 18.9 +/- 0.8 pmol/ml (x- +/- SEM). Between weeks 9-12 and 33-36 of gestation, there were two peaks, with a mean cAMP of 22.5 +/- 2.4 which were significantly increased in comparison to the other weeks of pregnancy. Significantly decreased values were found in patients with threatened abortion (weeks 12-28) which terminated in abortion (11.6 +/- 2.4; p < 0.01). In premature labor no differences were found. During therapy with fenoterol there were highly significantly increased plasma cAMP levels (48.2 +/- 2.8; p < 0.0005). During thyroid hormone therapy in euthyroid goiter, cAMP was significantly decreased (14.0 +/- 1.4; p < 0.05). 1 week after cessation of therapy a highly significant increase of cAMP was observed (38.2 +/- 6.9; p < 0.0005). There was a negative linear regression between T3 and cAMP (2p < 0.01). In pregnancy with hypertension cAMP was significantly elevated (30.5 +/- 3.8 p < 0.0005), but nearly normal under antihypertensive therapy. In pregnancy with edema only, no difference was found. Induction of labor with PGE2 alpha was followed by a decrease of plasma cAMP.
采用托维等人的方法测定血浆环磷腺苷（cAMP），正常孕妇血浆cAMP平均浓度为18.9±0.8皮摩尔/毫升（x-±标准误）。在妊娠第9 - 12周和第33 - 36周之间出现两个峰值，cAMP平均值为22.5±2.4，与妊娠其他周相比显著升高。在最终流产的先兆流产患者（第12 - 28周）中发现cAMP值显著降低（11.6±2.4；p<0.01）。早产患者未发现差异。在使用非诺特罗治疗期间，血浆cAMP水平显著升高（48.2±2.8；p<0.0005）。在甲状腺功能正常的甲状腺肿患者接受甲状腺激素治疗期间，cAMP显著降低（14.0±1.4；p<0.05）。治疗停止1周后，观察到cAMP显著升高（38.2±6.9；p<0.0005）。T3与cAMP之间存在负线性回归（2p<0.01）。妊娠合并高血压时cAMP显著升高（30.5±3.8，p<0.0005），但在抗高血压治疗下接近正常。仅妊娠合并水肿时未发现差异。用前列腺素E2α引产会导致血浆cAMP降低。
