Göser R, Briel R C, Breisch G, Jaschonek K, Schindler A E
Arch Gynecol. 1980;230(1):89-94. doi: 10.1007/BF02108600.
The mean platelet cyclic AMP (cAMP) value in normal pregnant women between 20 and 37 weeks of gestation was 8.2 +/- 0.4 (SEM) pmol cAMP/10(9) platelets (n = 100). From 35 patients with premature labor, 81 blood samples were obtained from measurement of the platelet cAMP before, during and after treatment with fenoterol/verapamil. During the first 4 days of therapy there was an increase of cAMP (p < 0.005); with long-term therapy the blood platelet cAMP was decreased (p < 0.005). Because platelet aggregation has a negative correlation with platelet cAMP, fenoterol should be used cautiously in patients with defective platelet function, in severe bleeding, and before surgery. With long-term treatment platelet aggregation may be increased and thus contribute to the formation of thrombi. Placental perfusion is not likely to be improved by increased platelet aggregation during long-term treatment with fenoterol.
妊娠20至37周正常孕妇的血小板环磷酸腺苷（cAMP）平均水平为8.2±0.4（标准误）pmol cAMP/10⁹血小板（n = 100）。从35例早产患者中，在使用非诺特罗/维拉帕米治疗前、治疗期间和治疗后采集了81份血液样本用于检测血小板cAMP。治疗的前4天cAMP升高（p < 0.005）；长期治疗后血小板cAMP降低（p < 0.005）。由于血小板聚集与血小板cAMP呈负相关，对于血小板功能缺陷患者、严重出血患者以及手术前患者，应谨慎使用非诺特罗。长期治疗可能会增加血小板聚集，从而促进血栓形成。长期使用非诺特罗治疗期间，血小板聚集增加不太可能改善胎盘灌注。
