衰老大鼠小脑β1 - 和β2 - 肾上腺素能受体密度的变化
Alterations in beta 1- and beta 2-adrenergic receptor density in the cerebellum of aging rats.
作者信息
Pittman R N, Minneman K P, Molinoff P B
出版信息
J Neurochem. 1980 Jul;35(1):273-5. doi: 10.1111/j.1471-4159.1980.tb12517.x.
The densities of beta 1 and beta 2-adrenergic receptors were determined in homogenates of cerebral cortex and cerebellum of rats between 3 and 14 mo of age. No change in either receptor population occurred in the cortex during this period. In the cerebellum, a 20--25% decrease in the density of beta 2 receptors and a 350% increase in the density of beta 1 receptors occurred. The increase in beta 1 receptors in the cerebellum may be the result of a decrease in the function of the noradrenergic projections from the locus coeruleus which synapse on cerebellar Purkinje cells.
测定了3至14月龄大鼠大脑皮层和小脑匀浆中β1和β2肾上腺素能受体的密度。在此期间，皮层中任一受体群体均未发生变化。在小脑中，β2受体密度下降了20%-25%，β1受体密度增加了350%。小脑中β1受体的增加可能是由于蓝斑去甲肾上腺素能投射到小脑浦肯野细胞的功能下降所致。
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