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提高十二指肠腺癌的生存率。

Improving survival in adenocarcinoma of the duodenum.

作者信息

Joesting D R, Beart R W, van Heerden J A, Weiland L H

出版信息

Am J Surg. 1981 Feb;141(2):228-31. doi: 10.1016/0002-9610(81)90163-x.

DOI:10.1016/0002-9610(81)90163-x
PMID:6257130
Abstract

The records of 104 patients with primary adenocarcinoma of the duodenum were reviewed. All patients were followed up to the date of this report, 91 for at least 5 years. Melena was an ominous preoperative finding. Survival was directly related to nodal status, the grade of the lesion, and the ability of the surgeon to minimize or eliminate operative mortality. Fifty percent of the lesions were resectable for cure, and the 5 year survival rate for patients with resectable lesions was 46 percent. All eight patients treated with segmental resections for lesions in the third and fourth portions of the duodenum survived at least 5 years. These data are a great improvement over those in previous reports and suggest that this disease may be much more treatable than previously believed.

摘要

回顾了104例十二指肠原发性腺癌患者的记录。所有患者均随访至本报告日期,91例至少随访了5年。黑便是术前不祥的表现。生存率与淋巴结状态、病变分级以及外科医生将手术死亡率降至最低或消除手术死亡率的能力直接相关。50%的病变可切除以治愈,可切除病变患者的5年生存率为46%。所有8例因十二指肠第三和第四部分病变接受节段性切除治疗的患者均存活至少5年。这些数据比以前的报告有了很大改善,表明这种疾病可能比以前认为的更具可治性。

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Improving survival in adenocarcinoma of the duodenum.提高十二指肠腺癌的生存率。
Am J Surg. 1981 Feb;141(2):228-31. doi: 10.1016/0002-9610(81)90163-x.
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KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma.KRAS G>A 突变有利于肿瘤分化不良,但与可切除十二指肠腺癌患者的预后可能无关。
Int J Cancer. 2013 Jun 1;132(11):2502-9. doi: 10.1002/ijc.27910. Epub 2013 Jan 18.
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Postoperative morbidity is an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma.原发性十二指肠腺癌行潜在可治愈性胰十二指肠切除术后,术后发病率是一个附加的预后因素。
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