de Brux J, Ionesco M, Cochard B, Masson M F, Kaeding H
J Gynecol Obstet Biol Reprod (Paris). 1980;9(6):613-20.
Because the greater number of viral cervical lesions, the authors recall their cytological and pathological pictures. In 30% of the causes, they have observed relations between flat condylomas and cervical severe dysplasias and carcinoma in situ. But in these last lesions, the cytological characters of the viral infestations are not visuable. The relationship between condyloma and carcinoma in situ is explained by the virus modifications on the germinative cells genoma which enhance great multiplication of these cells and inhibit the epidermoid differentiation. When the virus are not very active, or the host responses sufficient, the cell differentiation and maturation permit the replication of the virus and its appearance in the cytoplasm of the superficial cells. The authors stress on the complete destruction of the viral cervical lesions and the later control of the cervix.
由于宫颈病毒病变数量较多，作者回顾了其细胞学和病理学表现。在30%的病例中，他们观察到扁平湿疣与宫颈重度发育异常及原位癌之间的关联。但在这些后期病变中，病毒感染的细胞学特征不可见。湿疣与原位癌之间的关系可通过生发细胞基因组上的病毒改变来解释，这些改变促进了这些细胞的大量增殖并抑制了表皮分化。当病毒活性不高或宿主反应充分时，细胞分化和成熟允许病毒复制并出现在表层细胞的细胞质中。作者强调要彻底清除宫颈病毒病变并对宫颈进行后续监测。
