Pevzner L Z, Venkov L, Cheresharov L
Ukr Biokhim Zh (1978). 1978 Jan-Feb;50(1):20-4.
Albino rats were kept for a year under conditions of everyday motor loading or of a constant hypokinesia. An increase of the motor activity results in rise in the acetylcholinesterase activity determined in the synaptosomal and purified mitochondrial fractions while hypokinesia induces a pronounced decrease in this enzyme activity. The butyrylcholinesterase activity somewhat decreases in the synaptosomal fraction after hypokinesa but does not change under the motor loading regime. Motor loading causes an increase in the amount of synaptosomal water-soluble proteins possessing an intermediate electrophoretic mobility and seem to correspond to the brain-specific protein 14-3-2. In the synaptosomal fraction the amount of membrane proteins with a low electrophoretic mobility and with the cholinesterase activity rises. Hypokinesia, on the contrary, decreases the amount of these membrane proteins.
将白化大鼠置于日常运动负荷或持续运动不足的条件下饲养一年。运动活动的增加导致在突触体和纯化的线粒体组分中测定的乙酰胆碱酯酶活性升高，而运动不足则导致该酶活性显著降低。运动不足后，突触体组分中的丁酰胆碱酯酶活性略有下降，但在运动负荷条件下没有变化。运动负荷导致具有中等电泳迁移率且似乎对应于脑特异性蛋白14-3-2的突触体水溶性蛋白数量增加。在突触体组分中，具有低电泳迁移率和胆碱酯酶活性的膜蛋白数量增加。相反，运动不足会减少这些膜蛋白的数量。
