• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人类癌症的起源。

The origin of human cancers.

作者信息

Cairns J

出版信息

Nature. 1981 Jan 29;289(5796):353-7. doi: 10.1038/289353a0.

DOI:10.1038/289353a0
PMID:6258076
Abstract

The limited evidence available suggests that most human cancers are not caused by conventional mutagens but are more likely to be the result of genetic transpositions. Although the molecular biology of transposition is starting to be understood, the external factors that influence its frequency have not yet been studied in any detail.

摘要

现有有限的证据表明,大多数人类癌症并非由传统诱变剂引起,而更有可能是基因转座的结果。尽管转座的分子生物学开始为人所了解,但影响其频率的外部因素尚未得到详细研究。

相似文献

1
The origin of human cancers.人类癌症的起源。
Nature. 1981 Jan 29;289(5796):353-7. doi: 10.1038/289353a0.
2
Genes which increase chromosomal instability in somatic cells and predispose to cancer.在体细胞中增加染色体不稳定性并易患癌症的基因。
Prog Med Genet. 1972;8:61-101.
3
[Several genetic and evolutionary aspects of the problem of environmental pollution with mutagens].
Zh Evol Biokhim Fiziol. 1976 Nov-Dec;12(6):503-8.
4
Viral transformation of cells from persons at high risk of cancer.
Lancet. 1969 Jan 11;1(7585):81-2. doi: 10.1016/s0140-6736(69)91094-0.
5
The origin of viruses from cellular genetic material.
Enzymologia. 1972 Jul 31;43(1):13-8.
6
Xeroderma pigmentosum and Cockayne syndrome.着色性干皮病和科凯恩综合征。
Pediatrics. 1978 Apr;61(4):675-6.
7
Genes, pollutants and human diseases.基因、污染物与人类疾病。
Q Rev Biophys. 1978 Nov;11(4):603-27. doi: 10.1017/s0033583500005680.
8
Repair deficient human disorders and cancer.修复人类缺陷性疾病和癌症。
Nature. 1978 Feb 23;271(5647):713-7. doi: 10.1038/271713a0.
9
The susceptibility of the fetus and child to chemical pollutants. Viral etiology of cancer: two hypotheses with relevance to chemical exposures.胎儿和儿童对化学污染物的易感性。癌症的病毒病因:与化学暴露相关的两种假说。
Pediatrics. 1974 May;53(5):826-30.
10
Xeroderma pigmentosum: biochemical and genetic characteristics.着色性干皮病:生化及遗传特征
Annu Rev Genet. 1975;9:19-38. doi: 10.1146/annurev.ge.09.120175.000315.

引用本文的文献

1
Cancer research and the mainstream of biology.癌症研究与生物学主流
Front Cell Dev Biol. 2025 Jul 2;13:1623849. doi: 10.3389/fcell.2025.1623849. eCollection 2025.
2
Systematic Review and Clinical Insights: The Role of the Ketogenic Diet in Managing Glioblastoma in Cancer Neuroscience.系统评价与临床见解:生酮饮食在癌症神经科学中治疗胶质母细胞瘤的作用
J Pers Med. 2024 Aug 31;14(9):929. doi: 10.3390/jpm14090929.
3
Unraveling the anti-breast cancer activity of Cimicifugae rhizoma using biological network pathways and molecular dynamics simulation.
利用生物网络途径和分子动力学模拟揭示升麻的抗乳腺癌活性
Mol Divers. 2025 Feb;29(1):241-254. doi: 10.1007/s11030-024-10847-3. Epub 2024 Apr 13.
4
Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory?与体细胞突变理论相比,线粒体代谢理论能否更好地解释癌症的起源与治疗?
Metabolites. 2021 Aug 25;11(9):572. doi: 10.3390/metabo11090572.
5
Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency.内源性逆转录病毒元件在合子基因组激活过程中的功能与调控:对提高体细胞核移植效率的启示。
Biomolecules. 2021 Jun 2;11(6):829. doi: 10.3390/biom11060829.
6
The need for rapid therapeutic efficacy testing for cancer therapy.癌症治疗中快速疗效测试的必要性。
Exp Mol Pathol. 2020 Apr;113:104382. doi: 10.1016/j.yexmp.2020.104382. Epub 2020 Jan 23.
7
Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity.虚拟筛选和统计分析在新型咖啡因类似物分子设计中的应用,这些分子具有潜在的上皮抗癌活性。
Curr Pharm Des. 2018;24(5):576-594. doi: 10.2174/1381612823666170711112510.
8
Press-pulse: a novel therapeutic strategy for the metabolic management of cancer.按压脉冲:一种用于癌症代谢管理的新型治疗策略。
Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. eCollection 2017.
9
Friend or Foe: Epigenetic Regulation of Retrotransposons in Mammalian Oogenesis and Early Development.敌友之间:哺乳动物卵子发生和早期发育中逆转录转座子的表观遗传调控
Yale J Biol Med. 2016 Dec 23;89(4):487-497. eCollection 2016 Dec.
10
Cancer as a mitochondrial metabolic disease.癌症作为一种线粒体代谢疾病。
Front Cell Dev Biol. 2015 Jul 7;3:43. doi: 10.3389/fcell.2015.00043. eCollection 2015.