Vogt-Moykopf I, Lüllig H, Toomes H
Onkologie. 1980 Jun;3(3):112-9. doi: 10.1159/000214778.
In accordance with international statistics 25% of all patients with bronchogenic carcinoma can be treated by resection at the moment the diagnosis is established. The 5 year survival rate is in most series 25%. Important prognostic factors are: TNM-stage, histological classification, biological nature of the tumour and involvement of lymph nodes; discussed are further localisation of the primary tumour and immunological status. The summarizing statistics show that the carcinoma of squamous cell type has the best chance of a 5 year survival with a rate of more than 50%. In small-cell carcinoma extremely different 5 year survival rates between 0 and 20% are reported. In the surgical treatment it is obvious that the number of lobectomies are increasing in comparison to pneumonectomies. The postoperative mortality rate differs for "radical" pneumonectomy between 20% and 35%, for simple pneumonectomy between 7% and 10% and for lobectomy below 2%. Determinant for the postoperative course is the preoperative estimation of the risk factors. The 5 year survival rate after broncho- or angioplastic procedures varies in different series between 9,8% and 36%. In segmentectomies and wedge resections the 5 year survival rate was up to 56%. Primary palliative resections are indicated for pain reduction and improvement of the quality of life.
根据国际统计数据，在确诊时，所有支气管源性癌患者中有25%可以通过手术切除进行治疗。大多数系列研究中的5年生存率为25%。重要的预后因素包括：TNM分期、组织学分类、肿瘤的生物学特性和淋巴结受累情况；还讨论了原发肿瘤的进一步定位和免疫状态。总结统计表明，鳞状细胞型癌的5年生存几率最佳，生存率超过50%。据报道，小细胞癌的5年生存率差异极大，在0%至20%之间。在外科治疗中，与全肺切除术相比，肺叶切除术的数量明显增加。“根治性”全肺切除术的术后死亡率在20%至35%之间，单纯全肺切除术的术后死亡率在7%至10%之间，肺叶切除术的术后死亡率低于2%。术后病程的决定因素是术前对危险因素的评估。支气管或血管成形术后的5年生存率在不同系列研究中在9.8%至36%之间。在肺段切除术和楔形切除术中，5年生存率高达56%。原发性姑息性切除术适用于减轻疼痛和改善生活质量。
