Lewis M E, Mishkin M, Bragin E, Brown R M, Pert C B, Pert A
Science. 1981 Mar 13;211(4487):1166-9. doi: 10.1126/science.6258227.
In order to obtain information on the possible functions of endogenous opiates in the primate cerebral cortex, we assessed the distribution of mu-like opiate receptors (which selectively bind 3H-labeled naloxone) and delta-like opiate receptors (which selectively bind 3H-labeled D-Ala2, D-Leu5-enkephalin) throughout the cerebral cortex of the rhesus monkey. Stereospecific [3H]naloxone binding sites increased in a gradient along hierarchically organized cortical systems that sequentially process modality-specific sensory information of a progressively more complex nature. Specific [3H]enkephalin binding sites, in contrast, were relatively evenly distributed throughout the cerebral cortex. These results, in combination with electrophysiological studies of monkeys and humans, suggest that mu-like opiate receptors may play a role in the affective filtering of sensory stimuli at the cortical level, that is, in emotion-induced selective attention.
为了获取内源性阿片类物质在灵长类动物大脑皮层中可能的功能信息，我们评估了μ样阿片受体（可选择性结合3H标记的纳洛酮）和δ样阿片受体（可选择性结合3H标记的D-Ala2，D-Leu5-脑啡肽）在恒河猴整个大脑皮层中的分布。立体特异性[3H]纳洛酮结合位点沿着分层组织的皮层系统呈梯度增加，这些系统依次处理性质逐渐复杂的特定模态感觉信息。相比之下，特异性[3H]脑啡肽结合位点在整个大脑皮层中分布相对均匀。这些结果，结合对猴子和人类的电生理研究，表明μ样阿片受体可能在皮层水平的感觉刺激的情感过滤中起作用，也就是说，在情绪诱导的选择性注意中起作用。
