Wise S P, Herkenham M
Science. 1982 Oct 22;218(4570):387-9. doi: 10.1126/science.6289441.
The distribution of opiate receptors in the cerebral cortex of the rhesus monkey (Macaca mulatta) was determined by autoradiographic visualization of [3H]naloxone binding to tissue sections. Naloxone was bound in relatively large amounts to the cortical laminae containing the cell bodies of output neurons, to a varying set of additional laminae in different cortical fields, to fields closer to more primitive types of cortex, and to polysensory cortical fields. From these laminar and areal variations in distribution, it appears that opiate receptors play a role in specific aspects of cortical function.
通过对[3H]纳洛酮与恒河猴（猕猴）大脑皮质组织切片结合进行放射自显影可视化，确定了阿片受体在恒河猴大脑皮质中的分布。纳洛酮大量结合于含有输出神经元胞体的皮质层、不同皮质区域中一组不同的附加层、更接近原始皮质类型的区域以及多感觉皮质区域。从这些分布的层状和区域变化来看，阿片受体似乎在皮质功能的特定方面发挥作用。
