因分泌人绒毛膜促性腺激素的松果体瘤导致的性早熟（作者译）

[Precocious puberty due to HCG secreting pinealoma (author's transl)].

作者信息

Rosenberg D

出版信息

Sem Hop. 1981;57(1-2):68-73.

Abstract

The present report concerns a six years nine months old boy in whom a HCG secreting pineal tumor (pinealocytoma type I) was responsible for precocious puberty. Features : polydipsia, deepened voice, pubic hair, penile enlargement without corresponding testicular growth. Serum basal concentrations of LH (150 mU/ml), testosterone (85.80 nanomole/l), HCG (115 ng/ml) and its beta subunit (15 ng/ml) were markedly elevated, FSH was low (3.9 mU/ml) ] dissociated hypopituitarism was also present. A surgical removal of the tumor was performed (RIA of the neoplastic tissue revealed high HCG and beta HCG activity) and after the operation the child had radiation therapy. Recovery for the foregoing procedure was rapid, but after some months, in spite chemotherapy his condition deteriorated progressively. The apparent limitation of pinealoma and precocious puberty to the male sex is discussed and supposed to be partly the result of the ectopic gonadotropin secretion. These tumors are compared to other HCG secreting carcinomas located elsewhere in the body and causing sexual precocity in boys only.

摘要

本报告涉及一名6岁9个月大的男孩，其患有分泌人绒毛膜促性腺激素（HCG）的松果体肿瘤（I型松果体细胞瘤），导致性早熟。特征包括：烦渴、声音变粗、阴毛生长、阴茎增大但睾丸未相应生长。血清基础促黄体生成素（LH）浓度（150 mU/ml）、睾酮（85.80纳摩尔/升）、HCG（115 ng/ml）及其β亚基（15 ng/ml）显著升高，促卵泡生成素（FSH）较低（3.9 mU/ml），同时存在分离性垂体功能减退。对肿瘤进行了手术切除（肿瘤组织的放射免疫分析显示HCG和β-HCG活性较高），术后患儿接受了放射治疗。上述治疗过程恢复迅速，但几个月后，尽管进行了化疗，他的病情仍逐渐恶化。文中讨论了松果体瘤和性早熟明显局限于男性的情况，并推测部分是异位促性腺激素分泌的结果。将这些肿瘤与身体其他部位分泌HCG并仅导致男孩性早熟的其他癌进行了比较。