一名患有鞍上异位松果体瘤并伴有全垂体功能减退的女孩因异位人绒毛膜促性腺激素分泌导致青春期发育。

Puberty due to ectopic HCG production in a girl with suprasellar ectopic pinealoma associated with panhypopituitarism.

作者信息

Demura R, Kubo O, Kitamura K, Jibiki K, Odagiri E, Demura H, Shizume K

出版信息

Endocrinol Jpn. 1984 Feb;31(1):71-5. doi: 10.1507/endocrj1954.31.71.

DOI:10.1507/endocrj1954.31.71

Abstract

A 13.5-year-old girl who developed puberty due to HCG production by suprasellar ectopic pinealoma was reported. This girl appeared to be in a state of precocious puberty at the age of 5 when ectopic pinealoma was first diagnosed. Her breasts started to develop at 13 years of age in spite of hypopituitarism. Plasma LH was found to increase for several months and gave rise to suspicion of the recurrence of the tumor, which was confirmed by the detection of HCG in plasma and CSF. Precocious puberty or puberty can be a characteristic endocrinological manifestation of an HCG producing tumor not only in boys but also in girls. The measurement of plasma HCG (or LH) can be a useful tumor marker in following the clinical course of an HCG producing tumor.

摘要

报告了一名13.5岁因鞍上异位松果体瘤产生人绒毛膜促性腺激素（HCG）而出现性早熟的女孩。该女孩在5岁首次诊断出异位松果体瘤时似乎处于性早熟状态。尽管存在垂体功能减退，但她的乳房在13岁时开始发育。发现血浆促黄体生成素（LH）升高了几个月，这引起了肿瘤复发的怀疑，血浆和脑脊液中检测到HCG证实了这一点。性早熟或青春期不仅在男孩中，而且在女孩中都可能是产生HCG肿瘤的典型内分泌表现。血浆HCG（或LH）的测量在跟踪产生HCG肿瘤的临床过程中可能是一种有用的肿瘤标志物。