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Epoxide-diol pathway of delta 1-THC in the rat in vitro.

作者信息

Ben-Zvi Z

出版信息

Xenobiotica. 1980 Nov;10(11):805-9. doi: 10.3109/00498258009033810.

DOI:10.3109/00498258009033810
PMID:6258334
Abstract
  1. 1 alpha, 2 alpha-Epoxyhexahydrocannabinol was identified as a metabolite of delta 1-tetrahydrocannabinol. 2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1 alpha, 2 beta-dihydroxyhexahydrocannabinol and 1 beta, 2 alpha-dihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1 alpha, 2 alpha-epoxyhexahydrocannabinol with rat hepatic microsomes in vitro. 3. The 1 alpha, 2 alpha-epoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide. 4. The synthesis of metabolites of 1 alpha, 2 alpha-epoxyhexahydrocannabinol is described.
摘要

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