Glatt H, Ohlsson A, Agurell S, Oesch F
Mutat Res. 1979 Apr;66(4):329-35. doi: 10.1016/0165-1218(79)90043-0.
1,2-Epoxyhexahydrocannabinol is a metabolite of delta 1-tetrahydrocannabinol. Because many epoxides are mutagens, we investigated 1,2-epoxyhexahydrocannabinol as well as delta 1-tetrahydrocannabinol for mutagenicity with Salmonella typhimurium TA1535, TA1537, TA98 and TA100 in the presence and in the absence of S9 mix from liver homogenate of rats treated with Aroclor 1254. Additionally, an epoxide hydratase inhibitor was used in some experiments. Whereas several other epoxides and further positive controls, not requiring activation or activated under the same conditions, respectively, showed strong mutagenicity, no indications of a mutagenic hazard by 1,2-epoxyhexahydrocannabinol or by delta 1-tetrahydrocannabinol were found.
1,2-环氧六氢大麻酚是δ1-四氢大麻酚的一种代谢产物。由于许多环氧化物具有致突变性，我们在有和没有用Aroclor 1254处理的大鼠肝脏匀浆的S9混合物存在的情况下，用鼠伤寒沙门氏菌TA1535、TA1537、TA98和TA100研究了1,2-环氧六氢大麻酚以及δ1-四氢大麻酚的致突变性。此外，在一些实验中使用了环氧水解酶抑制剂。虽然其他几种环氧化物和另外的阳性对照分别在不需要活化或在相同条件下活化时显示出很强的致突变性，但未发现1,2-环氧六氢大麻酚或δ1-四氢大麻酚有致突变危害的迹象。
