Ashmarin I P, Antonova L V, Titov S A, Maksimova L A, Kamenskiĭ A A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1980 Nov-Dec;30(6):1196-1203.
The effect of two oligopeptides--ACTG4-10 and hexopeptide met-glu-his-D-phen-lis-L-phen (Dphen-GP) on memorizing the situation and on orienting-investigating reaction was studied in albino rats by the method of elaboration of food-procuring habit in T-maze and by the method of "open field". It was shown that these peptides in a dose of 15 mcg/kg with certain periods of administration, have an opposite effect on maze learning but a similar effect on memorizing in the "open field". ACTG4-10 slightly increases motor activity in the "open field", whereas Dphen-GP decreases it considerably. It is suggested that ACTG4-10 improves the formation of trace processes independently of the sign of reinforcement, whereas Dphen-GP selectively enhances defensive reaction and memorizing, connected with negative reinforcement.
通过在T型迷宫中培养获取食物习惯的方法以及“旷场”实验法，研究了两种寡肽——ACTG4 - 10和六肽met - glu - his - D - phen - lis - L - phen（Dphen - GP）对白化大鼠记忆情境和定向探究反应的影响。结果表明，这些肽在剂量为15 mcg/kg并在特定给药期时，对迷宫学习有相反的作用，但对“旷场”实验中的记忆有相似的作用。ACTG4 - 10在“旷场”中略微增加运动活性，而Dphen - GP则显著降低运动活性。有人提出，ACTG4 - 10独立于强化信号改善痕迹过程的形成，而Dphen - GP选择性增强与负强化相关的防御反应和记忆。
