Katz R J
Eur J Pharmacol. 1979 Feb 1;53(4):383-5. doi: 10.1016/0014-2999(79)90464-3.
The 4--10 fragment of adrenocorticotrophic hormone (ACTH4--10; Met-Glu-His-Phe-Arg-Trp-Gly) was administered intracerebroventricularly to C57Bl mice with and without concurrent systemic injection of a standard dose of morphine sulfate. Morphine produced stereotyped behavioral activation (running, environmental oblivion, Straub tail) which was antagonized in a dose related fashion by the ACTH fragment. This extends the range of opiate--ACTH4--10 interactions to a novel species and behavioral model, and is consistent with previous findings.
将促肾上腺皮质激素的4 - 10片段（促肾上腺皮质激素4 - 10；甲硫氨酸-谷氨酸-组氨酸-苯丙氨酸-精氨酸-色氨酸-甘氨酸）分别脑室内注射给C57Bl小鼠，部分小鼠同时全身注射标准剂量的硫酸吗啡。吗啡产生刻板行为激活（奔跑、忽视环境、Straub尾），促肾上腺皮质激素片段以剂量相关方式对抗这种激活。这将阿片类药物与促肾上腺皮质激素4 - 10相互作用的范围扩展到一个新的物种和行为模型，并且与先前的发现一致。
