Muñóz Villa A, Picazo M L, Fernández Epifanio J L, García-Miguel P, Gómez-Acebo F, González M C, Martínez Rubio A M, Durán J, González Utrilla J, Hurtado T
An Esp Pediatr. 1980 Sep;13(9):749-60.
79 cases of Wilms' tumor with age at diagnosis between 0 and eight years, are reported. 76 of them are evaluable for therapeutic results. 54 (71%) are alive and disease-free, with a mean survival of 53 months. Group A (35 patients) received pre-surgical treatment with radiotherapy and the survival rate is 77%. Group B (32 patients) were not treated before surgery and the survival rate is 84%. Both groups received post-surgical treatment with radiotherapy and chemotherapy (vincristine and actinomycin D). Patients in group C, chronologically the oldest, did not receive chemotherapy and its survival rate was 20%. Prognostical significance of age, sex, site, clinical stage and histology are examined. Classical concepts on histological classifications are revised and present criteria are shown, along with its' therapeutic and prognostic implications.
报告了79例诊断时年龄在0至8岁之间的肾母细胞瘤病例。其中76例可评估治疗结果。54例(71%)存活且无疾病,平均生存期为53个月。A组(35例患者)接受了术前放疗,生存率为77%。B组(32例患者)术前未接受治疗,生存率为84%。两组术后均接受了放疗和化疗(长春新碱和放线菌素D)。C组患者按时间顺序是年龄最大的,未接受化疗,其生存率为20%。研究了年龄、性别、部位、临床分期和组织学的预后意义。对组织学分类的传统概念进行了修订,并展示了当前标准及其治疗和预后意义。