正常妊娠及胎儿神经管缺陷时羊水中纤维蛋白（原）降解片段E和甲胎蛋白的水平
Amniotic fluid levels of fibrin(ogen) degradation fragment E and alpha-fetoprotein in normal pregnancy and with fetal neural tube defect.
作者信息
Gordon Y B, Ratky S M, Leighton P C, Kitau M J, Chard T
出版信息
Br J Obstet Gynaecol. 1976 Oct;83(10):771-4. doi: 10.1111/j.1471-0528.1976.tb00742.x.
Amniotic fluid levels of alpha-fetoprotein (AFP) and fibrin(ogen) degradation fragment E (FgE) were measured in 214 normal subjects and 27 pregnancies associated with an abnormal fetus (open neural tube defect or exomphalos). AFP levels showed no overlap between the normal and abnormal groups, thus confirming the reliability of the AFP assay in the detection of these abnormalities. FgE levels however showed considerable overlap and could not be used as a diagnostic parameter. Agarose gel chromatography of the amniotic fluid revealed the presence of large molecular weight FgE related antigen in open neural tube defect suggesting that leakage of proteins from exposed capillaries is responsible for the elevation of amniotic fluid protein levels.
在214名正常受试者以及27例与异常胎儿（开放性神经管缺陷或脐膨出）相关的妊娠中，检测了羊水甲胎蛋白（AFP）和纤维蛋白（原）降解片段E（FgE）的水平。AFP水平在正常组和异常组之间没有重叠，从而证实了AFP检测在这些异常检测中的可靠性。然而，FgE水平显示出相当大的重叠，不能用作诊断参数。羊水的琼脂糖凝胶色谱显示，开放性神经管缺陷中存在与FgE相关的大分子抗原，这表明暴露的毛细血管中蛋白质的渗漏是羊水蛋白质水平升高的原因。
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