Bond E B, Thompson W, Elwood J H, Cran G W
Br J Obstet Gynaecol. 1977 Aug;84(8):574-7. doi: 10.1111/j.1471-0528.1977.tb12655.x.
Maternal plasma alpha-fetoprotein (AFP) levels were estimated on 1844 consecutive patients at the time of their first hospital antenatal visits. There were 28 pregnancies with an 'abnormal' outcome: 19 patients had twins, 3 had an anencephalic fetus, and 6 a fetus with a spina bifida (4 of these had an open neural tube defect). Evaluation of maternal plasma AFP levels as a screening test for neural tube defects at 15 to 19 weeks gestation indicated a sensitivity of 50% taking the 'cut-off' point as the 95th centile of the plasma AFP levels in pregnancy with a normal outcome.
在1844名连续的患者首次产前就诊时，对其母血甲胎蛋白（AFP）水平进行了评估。有28例妊娠结局“异常”：19例患者怀有双胞胎，3例有无脑儿胎儿，6例有脊柱裂胎儿（其中4例有开放性神经管缺陷）。在妊娠15至19周时，将母血AFP水平作为神经管缺陷筛查试验进行评估，以正常妊娠母血AFP水平的第95百分位数作为“临界值”，结果显示其敏感性为50%。
