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1
A high-affinity cytosol binding protein for 1 alpha,25-dihydroxycholecalciferol in the uterus of Japanese quail.日本鹌鹑子宫中一种对1α,25 - 二羟基胆钙化醇具有高亲和力的胞质结合蛋白。
Biochem J. 1980 Sep 15;190(3):513-8. doi: 10.1042/bj1900513.
2
Calcium-binding protein and calcium absorption in the laying quail (Coturnix coturnix japonica).产蛋鹌鹑（日本鹌鹑）中的钙结合蛋白与钙吸收
Poult Sci. 1976 Mar;55(2):622-8. doi: 10.3382/ps.0550622.
3
The metabolism of cholecalciferol in the liver of Japanese quail (Coturnix coturnix japonica) with particular reference to the effects of oestrogen.日本鹌鹑（Coturnix coturnix japonica）肝脏中胆钙化醇的代谢，特别提及雌激素的影响。
Biochem J. 1979 Sep 15;182(3):745-50. doi: 10.1042/bj1820745.
4
1 alpha,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60).1α,25-二羟基胆钙化醇与一种人类髓系白血病细胞系（HL-60）。
Biochem J. 1982 Jun 15;204(3):713-9. doi: 10.1042/bj2040713.
5
Regulation of intestinal calcium absorption in the laying quail: independent of kidney vitamin D hydroxylation.产蛋鹌鹑肠道钙吸收的调节：独立于肾脏维生素D羟化作用。
J Nutr. 1976 Sep;106(9):1336-42. doi: 10.1093/jn/106.9.1336.
6
Specific binding of 1alpha,25-dihydroxycholecalciferol to nuclear components of chick intestine.1α,25-二羟胆钙化醇与鸡小肠核成分的特异性结合。
J Biol Chem. 1975 Feb 25;250(4):1588-94.
7
[Experimental studies of extraosseous calcification in hypervitaminosis D3. V. Light and electron microscopic localization of the calcium-binding protein (CaBP) in the uterus of laying quail].[维生素D3过多症时骨外钙化的实验研究。V. 产蛋鹌鹑子宫中钙结合蛋白（CaBP）的光镜和电镜定位]
Zentralbl Veterinarmed A. 1983 Apr;30(4):296-312.
8
Gel-permeation high-performance liquid chromatography as a powerful technique for rapid analysis of calcitriol (1,25-dihydroxycholecalciferol) receptors.凝胶渗透高效液相色谱法作为快速分析骨化三醇（1,25-二羟基胆钙化醇）受体的强大技术。
Biochem J. 1983 Jan 1;209(1):223-7. doi: 10.1042/bj2090223.
9
Binding of 1,25-dihydroxy-[3H]vitamin D3 in nuclear and cytosol fractions of whole mouse skin in vivo and in vitro.1,25-二羟基-[3H]维生素D3在体内和体外全小鼠皮肤的细胞核及胞浆组分中的结合情况。
FEBS Lett. 1981 Nov 16;134(2):203-6. doi: 10.1016/0014-5793(81)80602-3.
10
Normal egg hatchability requires the simultaneous administration to the hen of 1 alpha,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol.正常的孵化率要求同时给母鸡投喂1α,25-二羟基胆钙化醇和24R,25-二羟基胆钙化醇。
J Nutr. 1983 Dec;113(12):2505-15. doi: 10.1093/jn/113.12.2505.

引用本文的文献

1
1 alpha,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60).1α,25-二羟基胆钙化醇与一种人类髓系白血病细胞系（HL-60）。
Biochem J. 1982 Jun 15;204(3):713-9. doi: 10.1042/bj2040713.
2
Biochemical characterization of 1,25(OH)2D3 receptors in chick embryonal duodenal cytosol.鸡胚十二指肠细胞质中1,25(OH)₂D₃受体的生化特性
Calcif Tissue Int. 1982 May;34(3):265-9. doi: 10.1007/BF02411248.

本文引用的文献

1
A rapid method of total lipid extraction and purification.一种快速的总脂质提取与纯化方法。
Can J Biochem Physiol. 1959 Aug;37(8):911-7. doi: 10.1139/o59-099.
2
Rapid enhancement of chick intestinal DNA-dependent RNA polymerase II activity by 1 alpha, 25-dihydroxyvitamin D3, in vivo.1α,25 - 二羟基维生素D3在体内对雏鸡肠道DNA依赖性RNA聚合酶II活性的快速增强作用。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2337-41. doi: 10.1073/pnas.71.6.2337.
3
Intranuclear localization and receptor proteins for 1,25-dihydroxycholecalciferol in chick intestine.1,25-二羟胆钙化醇在鸡肠道中的核内定位及受体蛋白
Biochem J. 1974 Dec;144(3):573-83. doi: 10.1042/bj1440573.
4
1 Alpha,25-dihydroxycholecalciferol receptors in intestine. II. Temperature-dependent transfer of the hormone to chromatin via a specific cytosol receptor.1 肠道中的α,25-二羟胆钙化醇受体。II. 激素通过特定胞质溶胶受体向染色质的温度依赖性转移。
J Biol Chem. 1974 Feb 25;249(4):1258-62.
5
Vitamin D-induced synthesis of mRNA for calcium-binding protein.维生素D诱导钙结合蛋白mRNA的合成。
Nature. 1973 Nov 9;246(5428):100-1. doi: 10.1038/246100a0.
6
Vitamin D-dependent calcium-binding protein. Purification and some properties.维生素D依赖性钙结合蛋白。纯化及某些特性。
J Biol Chem. 1968 Jul 25;243(14):3978-86.
7
Vitamin D3 induction of a calcium-binding protein in the uterus of the laying hen.维生素D3对产蛋母鸡子宫中一种钙结合蛋白的诱导作用。
Arch Biochem Biophys. 1968 Apr;125(1):378-80. doi: 10.1016/0003-9861(68)90674-7.
8
The story of vitamin D: from vitamin to hormone.维生素D的故事：从维生素到激素。
Lancet. 1974 Mar 2;1(7853):325-9.
9
Intestinal and uterine calcium-binding protein in laying hens during different stages of egg formation.产蛋母鸡在不同产蛋阶段的肠道和子宫钙结合蛋白
Poult Sci. 1975 Jul;54(4):1325-7. doi: 10.3382/ps.0541325.
10
The transport of vitamin D and its 25-hydroxy metabolite in human plasma. Isolation and partial characterization of vitamin D and 25-hydroxyvitamin D binding protein.维生素D及其25-羟基代谢物在人血浆中的转运。维生素D和25-羟基维生素D结合蛋白的分离及部分特性鉴定。
J Clin Invest. 1976 Aug;58(2):514-23. doi: 10.1172/JCI108495.

日本鹌鹑子宫中一种对1α,25 - 二羟基胆钙化醇具有高亲和力的胞质结合蛋白。

A high-affinity cytosol binding protein for 1 alpha,25-dihydroxycholecalciferol in the uterus of Japanese quail.

作者信息

Takahashi N, Abe E, Tanabe R, Suda T

出版信息

Biochem J. 1980 Sep 15;190(3):513-8. doi: 10.1042/bj1900513.

DOI:10.1042/bj1900513
PMID:6258571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162126/
Abstract

Cytosol fractions prepared from the uterine mucosa of egg-laying Japanese Quail were analysed for binding of the metabolites of cholecalciferol. When the uterus was incubated at 37 degrees C with various radioactive metabolites of cholecalciferol, the nuclear fraction incorporated only 1 alpha,25-dihydroxy[3H]cholecalciferol. When the uterus was incubated at 0 degree C with 1 alpha,25-dihydroxy[3H]cholecalciferol, most of the radioactivity was found in the cytosol. Translocation of 1 alpha,25-dihydroxy[3H]cholecalciferol from the cytosol to the nucleus was temperature-dependent. The addition of 100-fold excess amounts of unlabelled 1 alpha-25-dihydroxycholecalciferol significantly diminished the nuclear binding of 1 alpha,25-dihydroxy[3H]cholecalciferol. The cytosol fraction contained a 3.5 S macromolecule that specifically binds 1 alpha,25-dihydroxy[3H]cholecalciferol. The dissociation constant was 0.39 nM and the maximal binding was 55 fmol/mg of protein. These results strongly suggest that the uterus in egg-laying birds is a target organ or 1 alpha,25-dihydroxycholecalciferol.

摘要

对产卵期日本鹌鹑子宫黏膜制备的胞质溶胶组分进行了胆钙化醇代谢物结合分析。当子宫在37℃下与各种放射性胆钙化醇代谢物一起孵育时，核组分仅摄取1α,25 - 二羟基[3H]胆钙化醇。当子宫在0℃下与1α,25 - 二羟基[3H]胆钙化醇一起孵育时，大部分放射性出现在胞质溶胶中。1α,25 - 二羟基[3H]胆钙化醇从胞质溶胶向细胞核的转运是温度依赖性的。加入100倍过量的未标记1α - 25 - 二羟基胆钙化醇可显著减少1α,25 - 二羟基[3H]胆钙化醇的核结合。胞质溶胶组分含有一种特异性结合1α,25 - 二羟基[3H]胆钙化醇的3.5S大分子。解离常数为0.39 nM，最大结合量为55 fmol/mg蛋白质。这些结果有力地表明，产卵鸟类的子宫是1α,25 - 二羟基胆钙化醇的靶器官。