去甲肾上腺素对大鼠脂肪细胞镁离子依赖性磷脂酸磷酸水解酶的失活作用。
The inactivation of rat adipocyte Mg2+-dependent phosphatidate phosphohydrolase by noradrenaline.
作者信息
Cheng C H, Saggerson E D
出版信息
Biochem J. 1980 Sep 15;190(3):659-62. doi: 10.1042/bj1900659.
Abstract
The inactivation of rat adipocyte Mg2+-dependent phosphatidate phosphohydrolase by noradrenaline [Cheng & Saggerson (1978) FEBS Lett. 87, 65--68; Cheng & Saggerson (1978) FEBS Lett. 93, 120--124] persists for at least 40 min in crude defatted homogenates kept at 0 degrees C or 20 degrees C, but is diminished at 37 degrees C. The effect of noradrenaline persists through the isolation of post-105000 g supernatants and is then stable in these preparations at 0 degrees C and 37 degrees C. Inclusion of albumin (10--20 mg/ml) in homogenization buffers abolishes the effect of noradrenaline. The effect of noradrenaline is not removed by dialysis of extracts or by raising the concentrations of Mg2+ or phosphatidate in assays.
摘要
去甲肾上腺素对大鼠脂肪细胞镁离子依赖性磷脂酸磷酸水解酶的失活作用[Cheng和Saggerson（1978年），《欧洲生物化学学会联合会快报》87卷，65 - 68页；Cheng和Saggerson（1978年），《欧洲生物化学学会联合会快报》93卷，120 - 124页]，在0℃或20℃保存的粗制脱脂匀浆中至少持续40分钟，但在37℃时会减弱。去甲肾上腺素的作用在分离105000g以上的上清液后仍然存在，然后在这些制剂中于0℃和37℃时保持稳定。在匀浆缓冲液中加入白蛋白（10 - 20mg/ml）可消除去甲肾上腺素的作用。去甲肾上腺素的作用不会因提取物的透析或在测定中提高镁离子或磷脂酸的浓度而消除。
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