Francavilla A, Sansonno D, Ierardi E, Amoruso A
Boll Soc Ital Biol Sper. 1980 Dec 30;56(24):2588-93.
The effect of glucagon on fasting gastrin levels was studied in normal subjects and in patients with advanced liver cirrhosis. Intravenous glucagon was given e.v. at a dose of 200 ng/kg/h and produced a significant decrease of serum gastrin levels at 50 min in controls while in cirrhotic patients there was no significant decrease. (p less than 0,01) Gastrin inhibition in normal subjects during glucagon infusion was significantly correlated to a simultaneous increase found in plasma cAMP and glucose levels. These findings suggest that hypergastrinemia in cirrhosis could be consequence of the failure of glucagon metabolic interactions.
在正常受试者和晚期肝硬化患者中研究了胰高血糖素对空腹胃泌素水平的影响。以200 ng/kg/h的剂量静脉注射胰高血糖素，对照组在50分钟时血清胃泌素水平显著降低，而肝硬化患者则无显著降低。（p<0.01）在正常受试者中，胰高血糖素输注期间胃泌素的抑制与血浆cAMP和葡萄糖水平同时升高显著相关。这些发现表明，肝硬化患者的高胃泌素血症可能是胰高血糖素代谢相互作用失败的结果。
