Francavilla A, Jones A F, Starzl T E
Gastroenterology. 1978 Dec;75(6):1026-32.
Glucagon was tested for its effect on plasma adenosine 3',5'-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused a significant increase in plasma cyclic AMP, glucose, and insulin. In advanced cirrhotics, plasma cyclic AMP, glucose, and insulin did not increase. Adenylate cyclase concentration was measured in liver tissue from end stage cirrhotic patients and from brain-dead organ donors whose cardiovascular function was maintained in a stable state. Basal and total adenylate cyclase concentration were not different in the two groups. Adenylate cyclase from the livers of advanced cirrhotics was, however, significantly less responsive to glucagon stimulation than was that from donor livers. Hepatocytes in advanced cirrhosis have abnormal metabolic behavior characterized by abnormal adenylate cyclase-cyclic AMP response to hormonal stimulation.
对健康受试者和晚期肝硬化患者测试了胰高血糖素对血浆3',5'-环磷酸腺苷（环磷腺苷）、胰岛素和葡萄糖的影响。在正常受试者中，静脉输注胰高血糖素导致血浆环磷腺苷、葡萄糖和胰岛素显著增加。在晚期肝硬化患者中，血浆环磷腺苷、葡萄糖和胰岛素并未增加。对终末期肝硬化患者以及心血管功能维持稳定状态的脑死亡器官供体的肝脏组织进行了腺苷酸环化酶浓度测定。两组的基础腺苷酸环化酶浓度和总腺苷酸环化酶浓度并无差异。然而，晚期肝硬化患者肝脏的腺苷酸环化酶对胰高血糖素刺激的反应明显低于供体肝脏的腺苷酸环化酶。晚期肝硬化中的肝细胞具有异常的代谢行为，其特征是腺苷酸环化酶 - 环磷腺苷对激素刺激的反应异常。
