β-肾上腺素能受体的刺激与阻断对扑热息痛吸收的影响。
The effect on paracetamol absorption of stimulation and blockade of beta-adrenoceptors.
作者信息
Clark R A, Holdsworth C D, Rees M R, Howlett P J
出版信息
Br J Clin Pharmacol. 1980 Dec;10(6):555-9. doi: 10.1111/j.1365-2125.1980.tb00510.x.
Abstract
1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose related, and blocked by prior administration of propranolol. 3 When isoprenaline was given immediately before the paracetamol, absorption was not altered, although a cardiovascular response was seen. 4 Oral salbutamol also delayed paracetamol absorption. 5 Propranolol given alone increased the rate of paracetamol absorption. 6 These results with the changes in the rate of gastric emptying produced by these agents.
摘要
- 在26名志愿者和9名轻度高血压患者中研究了作用于β-肾上腺素受体的药物对扑热息痛吸收和排泄的影响，每位受试者均作为自身对照。2. 在扑热息痛给药前30分钟给予异丙肾上腺素可显著减慢吸收，该效应与剂量相关，并可被预先给予的普萘洛尔阻断。3. 当在扑热息痛给药前立即给予异丙肾上腺素时，吸收未改变，尽管出现了心血管反应。4. 口服沙丁胺醇也延迟了扑热息痛的吸收。5. 单独给予普萘洛尔可提高扑热息痛的吸收速率。6. 这些结果与这些药物引起的胃排空速率变化有关。
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