β1和β2肾上腺素能受体在犬胃酸分泌抑制中的作用。
The role of beta1- and beta2-adrenoceptors in the inhibition of gastric acid secretion in the dog.
作者信息
Daly M J, Long J M, Stables R
出版信息
Br J Pharmacol. 1978 Sep;64(1):153-7. doi: 10.1111/j.1476-5381.1978.tb08652.x.
Abstract
- Characterization of the beta-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion. 2. The gastric antisecretory effect of salbutamol was significantly blocked by propranolol and H35/25 but not by practolol or (+)-propranolol. The effect of isoprenaline was significantly blocked by propranolol and practolol but not by H35/25 or (+)-propranolol. 3. It is concluded that both beta1- and beta2-adrenoceptors can mediate inhibition of pentagastrin-induced gastric secretion in conscious dogs with a Heidenhain pouch. Salbutamol exerts its antisecretory effect through beta2-adrenoceptors, whereas isoprenaline mediates its effects primarily through beta1-adrenoceptors. 4. The results are discussed with regard to the sub-classification of beta-adrenoceptors and to the possible role of adrenoceptors in the physiological control of gastric secretion. 5. In this study it is concluded that the tachycardia induced by isoprenaline or salbutamol is mediated primarily through reflexes activated by beta2-adrenoceptor mediated vasodilatation.
摘要
- 通过测定普萘洛尔、（+）-普萘洛尔、普拉洛尔和H35/25对沙丁胺醇和异丙肾上腺素诱导的胃酸分泌抑制作用，研究了介导清醒海登海因小胃犬胃酸分泌抑制的β-肾上腺素能受体特性。2. 普萘洛尔和H35/25可显著阻断沙丁胺醇的胃抗分泌作用，而普拉洛尔或（+）-普萘洛尔则不能。普萘洛尔和普拉洛尔可显著阻断异丙肾上腺素的作用，而H35/25或（+）-普萘洛尔则不能。3. 得出结论，β1-和β2-肾上腺素能受体均可介导清醒海登海因小胃犬中五肽胃泌素诱导的胃酸分泌抑制。沙丁胺醇通过β2-肾上腺素能受体发挥其抗分泌作用，而异丙肾上腺素主要通过β1-肾上腺素能受体介导其作用。4. 就β-肾上腺素能受体的亚分类以及肾上腺素能受体在胃酸分泌生理控制中的可能作用进行了讨论。5. 在本研究中得出结论，异丙肾上腺素或沙丁胺醇诱导的心动过速主要通过β2-肾上腺素能受体介导的血管舒张激活的反射来介导。
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