Golubykh V L
Biull Eksp Biol Med. 1980 Dec;90(12):656-9.
Ther coronary blood flow, arterial pressure, left ventricular pressure, frequency of cardiac contractions and resistance of coronary vessels were measured in dogs anesthetized with urethane by the end of diastole. At the 5th second after the start of the bipolar stimulation of the hypothalamic mamillary lateral nuclei (1--4 v, 100 Hz, 2 msec, duration 45 sec) the increased resistance of coronary vessels, which changed at the 15th second after the start of stimulation to the decrease of the resistance have been reported. In some cases, the unipolar stimulation of the same hypothalamic nuclei (5--10 v, 100 Hz, 2 msec, duration 45 sec) resulted in the increased resistance of coronary vessels during the whole stimulation period. Intracoronary administration of propranolol in the presence of stimulation, both bipolar and unipolar, of hypothalamic mamillary lateral nuclei increased coronary constriction, changing the reaction of vasodilatation of coronary vessels towards the reaction of vasoconstriction accompanied by the decreased coronary flow and considerable elevation of arterial pressure.
在舒张期末，对用氨基甲酸乙酯麻醉的犬测量其冠状动脉血流量、动脉压、左心室压力、心脏收缩频率和冠状动脉阻力。在下丘脑乳头体外侧核双极刺激开始后第5秒（1 - 4伏，100赫兹，2毫秒，持续45秒），据报道冠状动脉阻力增加，在刺激开始后第15秒变为阻力降低。在某些情况下，对相同下丘脑核进行单极刺激（5 - 10伏，100赫兹，2毫秒，持续45秒）会导致在整个刺激期间冠状动脉阻力增加。在刺激下丘脑乳头体外侧核（双极和单极）的情况下，冠状动脉内给予普萘洛尔会增加冠状动脉收缩，使冠状动脉血管舒张反应转变为血管收缩反应，同时伴有冠状动脉血流量减少和动脉压显著升高。
