[Regulation of coronary circulation during acute experimental stimulation of emotiogenic zones of the hypothalamus in dogs].

Ther coronary blood flow, arterial pressure, left ventricular pressure, frequency of cardiac contractions and resistance of coronary vessels were measured in dogs anesthetized with urethane by the end of diastole. At the 5th second after the start of the bipolar stimulation of the hypothalamic mamillary lateral nuclei (1--4 v, 100 Hz, 2 msec, duration 45 sec) the increased resistance of coronary vessels, which changed at the 15th second after the start of stimulation to the decrease of the resistance have been reported. In some cases, the unipolar stimulation of the same hypothalamic nuclei (5--10 v, 100 Hz, 2 msec, duration 45 sec) resulted in the increased resistance of coronary vessels during the whole stimulation period. Intracoronary administration of propranolol in the presence of stimulation, both bipolar and unipolar, of hypothalamic mamillary lateral nuclei increased coronary constriction, changing the reaction of vasodilatation of coronary vessels towards the reaction of vasoconstriction accompanied by the decreased coronary flow and considerable elevation of arterial pressure.