Tsybenko V A
Fiziol Zh SSSR Im I M Sechenova. 1977 Jan;63(1):94-103.
The blood flow in the lung lobe perfused under constant pressure was recorded with photoelectric drop recorder in acute closed-chest experiments in anesthetized dogs. Stimulation of supraoptic and lateral mamillary nuclei in most cases decreased flow rate and increased vascular resistance in perfused pulmonary lobe, while stimulation of sympatho-inhibitory area exerted opposite effect. Bilateral vagotomy and administration of atropin and inderal did not block the lesser circulation responses to the hypothalamic stimulation. However, phentolamine and bilateral ablation of stellate and upper thoracic ganglia eliminated chnages of blood flow and vascular resistance in the perfused lobe. The data obtained suggest that stimulation of some hypothalamic areas evoke obvious vasomotor responses in the lesser circulation and that these responses occur mainly through alpha-adrenergic sympathetic innervation of pulmonary vessels.
在麻醉犬的急性闭胸实验中，用光电滴数记录器记录在恒压下灌注的肺叶中的血流。在大多数情况下，刺激视上核和乳头体外侧核会降低灌注肺叶的血流速度并增加血管阻力，而刺激交感抑制区则产生相反的效果。双侧迷走神经切断术以及给予阿托品和心得安并不能阻断下丘脑刺激引起的微循环反应。然而，酚妥拉明以及双侧切除星状神经节和上胸段神经节可消除灌注肺叶中的血流和血管阻力变化。所获得的数据表明，刺激某些下丘脑区域会在微循环中引起明显的血管运动反应，并且这些反应主要通过肺血管的α-肾上腺素能交感神经支配发生。
