[黄嘌呤氧化酶——作为磷酸二酯酶活性内源性调节系统的黄嘌呤]
[Xanthine oxidase--xanthines as a system of endogenous regulation of phosphodiesterase activity].
作者信息
Kozhemiakin L A, Koroleva T R, Korostovtsev D S
出版信息
Biull Eksp Biol Med. 1980 Dec;90(12):673-5.
PMID:6258665
Abstract
The paper is concerned with the data indicating close interaction between xanthinoxidase (Xase) and phosphodiesterase (PDE). PDE activity can be modified by affecting the activity of Xase. This effect is mediated by changes in the concentrations of endogenous xanthines. The action of PDE inhibitors, methylxanthines, is discussed from the point of view of the above effect. The data obtained hold promise for purposeful monitoring of tissue concentrations of the cyclic nucleotides in vivo and in vitro.
摘要
本文关注的是表明黄嘌呤氧化酶（Xase）与磷酸二酯酶（PDE）之间存在密切相互作用的数据。PDE的活性可通过影响Xase的活性来改变。这种效应是由内源性黄嘌呤浓度的变化介导的。从上述效应的角度讨论了PDE抑制剂甲基黄嘌呤的作用。所获得的数据为在体内和体外有目的地监测环核苷酸的组织浓度带来了希望。
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[Xanthine oxidase--xanthines as a system of endogenous regulation of phosphodiesterase activity].[黄嘌呤氧化酶——作为磷酸二酯酶活性内源性调节系统的黄嘌呤]
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