随着胎羊年龄增长，心肌α-肾上腺素能受体浓度降低。
Decreased concentration of myocardial alpha-adrenoceptors with increasing age in foetal lambs.
作者信息
Cheng J B, Cornett L E, Goldfien A, Roberts J M
出版信息
Br J Pharmacol. 1980 Dec;70(4):515-7. doi: 10.1111/j.1476-5381.1980.tb09769.x.
Abstract
Using [3H]-dihydroergocryptine, we identified myocardial alpha-adrenoceptor binding sites in foetal lambs and demonstrated that the concentration of receptors decreased with increasing foetal age. The presence of the receptor in the foetus correlated with the presence of myocardial alpha-adrenergic responsiveness. However, we found neither the alpha-receptor binding site nor responsiveness to alpha-adrenoceptor stimulation in the myocardium of adult sheep.
摘要
使用[3H]-二氢麦角隐亭，我们在胎羊中鉴定出心肌α-肾上腺素能受体结合位点，并证明受体浓度随胎龄增加而降低。胎儿体内该受体的存在与心肌α-肾上腺素能反应性的存在相关。然而，我们在成年绵羊的心肌中既未发现α-受体结合位点，也未发现对α-肾上腺素能受体刺激的反应性。
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