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一种突触后α2受体:仓鼠白色脂肪细胞的α-肾上腺素能受体。

A postsynaptic alpha 2-receptor: the alpha-adrenergic receptor of hamster white fat cells.

作者信息

Carpéné C, Lafontan M, Berlan M

出版信息

Experientia. 1980 Dec 15;36(12):1413-4. doi: 10.1007/BF01960132.

DOI:10.1007/BF01960132
PMID:6258969
Abstract

The effects of selected alpha-agonists and alpha-antagonists on theophylline-induces lipolysis were investigate in isolated hamster white fat cells, alpha 2-Agonists (tramazoline, clonidine) inhibited theophylline-induced lipolysis while in alpha 1-agonist (methoxamine) was without any effect. The inhibitory effect of alpha 2-agonists was suppressed by yohimbine (alpha 2-antagonist), whereas alpha 1-antagonists were inefficient. This result implies that the alpha-adrenergic receptor of hamster fat cells is of the alpha 2-type, although postsynaptically.

摘要

在分离的仓鼠白色脂肪细胞中研究了几种α-激动剂和α-拮抗剂对茶碱诱导的脂肪分解的影响。α2-激动剂(曲马唑啉、可乐定)抑制茶碱诱导的脂肪分解,而α1-激动剂(甲氧明)则无任何作用。育亨宾(α2-拮抗剂)可抑制α2-激动剂的抑制作用,而α1-拮抗剂则无效。这一结果表明,仓鼠脂肪细胞的α-肾上腺素能受体虽然是突触后受体,但属于α2型。

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Experientia. 1980 Dec 15;36(12):1413-4. doi: 10.1007/BF01960132.
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引用本文的文献

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[3H]-idazoxan binds with high affinity to two sites on hamster adipocytes: an alpha 2-adrenoceptor and a non-adrenoceptor site.[3H]-咪唑克生以高亲和力与仓鼠脂肪细胞上的两个位点结合:一个α2-肾上腺素能受体位点和一个非肾上腺素能受体位点。
Br J Pharmacol. 1989 Dec;98(4):1143-50. doi: 10.1111/j.1476-5381.1989.tb12658.x.

本文引用的文献

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Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
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Roles of alpha and beta adrenergic receptors in control of glucose oxidation in hamster epididymal adipocytes.α和β肾上腺素能受体在仓鼠附睾脂肪细胞葡萄糖氧化调控中的作用。
Biochim Biophys Acta. 1976 Apr 23;428(2):379-87. doi: 10.1016/0304-4165(76)90045-3.
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Inhibition of lipolysis in hamster epididymal adipocytes by selective alpha-adrenergic agents. Evidence for cyclic AMP-dependent and independent mechanisms.选择性α-肾上腺素能药物对仓鼠附睾脂肪细胞脂解作用的抑制。环磷酸腺苷依赖性和非依赖性机制的证据。
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Distinct alpha-noradrenergic receptors differentiated by binding and physiological relationships.通过结合和生理关系区分的不同α-去甲肾上腺素能受体。
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