催乳素对人体红细胞钠转运的影响。

Effect of prolactin on human red cell sodium transport.

作者信息

Gopalakrishnan V, Ramaswamy S, Pillai N P, Ranganathan S, Ghosh M N

出版信息

Experientia. 1980 Dec 15;36(12):1423-5. doi: 10.1007/BF01960139.

DOI:10.1007/BF01960139

Abstract

Incubation of red cells with higher concentrations of prolactin in vitro enhanced the cellular sodium level and produced a significant reduction in erythrocyte membrane adenosine triphosphatase activity. This effect was dose and time-dependent. It is the result of an inhibition of the active sodium pump similar to that produced by ouabain, suggesting altered red cell function and electrolyte balance in hyperprolactinemic states.

摘要

体外将红细胞与更高浓度的催乳素孵育会提高细胞内钠水平，并使红细胞膜三磷酸腺苷酶活性显著降低。这种效应呈剂量和时间依赖性。这是对活性钠泵的抑制作用的结果，类似于哇巴因所产生的抑制作用，提示高催乳素血症状态下红细胞功能和电解质平衡发生了改变。