慢性普萘洛尔治疗对垂体前叶及相关激素夜间血浆水平的影响。
The effect of chronic propranolol treatment on overnight plasma levels of anterior pituitary and related hormones.
作者信息
Dart A M, Lewis M J, Groom G V, Meek E M, Henderson A H
出版信息
Br J Clin Pharmacol. 1981 Dec;12(6):849-53. doi: 10.1111/j.1365-2125.1981.tb01319.x.
Abstract
1 Treatment of eight healthy males with propranolol (80 mg twice daily) for 6 weeks resulted in a significant reduction in overnight plasma levels of prolactin and LH. 2 Plasma testosterone levels were elevated whilst GH and cortisol were unchanged by such treatment. 3 Measurement of overnight hormone levels 48 h after discontinuing treatment showed no evidence of a 'rebound' phenomenon. 4 Cortisol, GH, prolactin, and testosterone plasma levels all showed time dependent changes: propranolol treatment significantly altered the time course of cortisol but not of the other hormones. 5 The effects of chronic propranolol treatment are discussed in terms of a probable direct central action of the drug. In addition the lowered plasma prolactin levels may directly contribute to the hypotensive action of propranolol.
摘要
- 对8名健康男性每日两次服用普萘洛尔（80毫克），持续6周，结果显示夜间催乳素和促黄体生成素的血浆水平显著降低。2. 血浆睾酮水平升高，而生长激素和皮质醇水平在这种治疗下未发生变化。3. 在停药48小时后测量夜间激素水平，未发现“反跳”现象。4. 皮质醇、生长激素、催乳素和睾酮的血浆水平均呈现出时间依赖性变化：普萘洛尔治疗显著改变了皮质醇的时间进程，但对其他激素没有影响。5. 从该药物可能的直接中枢作用方面讨论了慢性普萘洛尔治疗的效果。此外，血浆催乳素水平降低可能直接有助于普萘洛尔的降压作用。
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本文引用的文献
1
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Br J Clin Pharmacol. 1980 Jan;9(1):57-60. doi: 10.1111/j.1365-2125.1980.tb04797.x.
2
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Br J Clin Pharmacol. 1981 Nov;12(5):737-42. doi: 10.1111/j.1365-2125.1981.tb01298.x.
3
Effect of prolactin on human red cell sodium transport.催乳素对人体红细胞钠转运的影响。
Experientia. 1980 Dec 15;36(12):1423-5. doi: 10.1007/BF01960139.
4
Effect of intravenous prolactin infusion on arterial blood pressure in rabbits.静脉注射催乳素对家兔动脉血压的影响。
Cardiovasc Res. 1973 Sep;7(5):585-7. doi: 10.1093/cvr/7.5.585.
5
Sleep-related, nychthermeral and briefly episodic variation in human plasma prolactin concentrations.
J Clin Endocrinol Metab. 1973 Jun;36(6):1119-24. doi: 10.1210/jcem-36-6-1119.
6
ACTH and cortisol secretory patterns in man.人类促肾上腺皮质激素（ACTH）和皮质醇的分泌模式。
J Clin Endocrinol Metab. 1973 Jun;36(6):1058-68. doi: 10.1210/jcem-36-6-1058.
7
Initial clinical experience with I.C.I. 66.082, a new beta-adrenergic blocking agent, in hypertension.新型β-肾上腺素能阻滞剂ICI 66.082治疗高血压的初步临床经验。
Acta Med Scand. 1973 Dec;194(6):549-50. doi: 10.1111/j.0954-6820.1973.tb19489.x.
8
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9
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Nature. 1975 Jul 31;256(5516):440. doi: 10.1038/256440a0.
10
Nocturnal increase of plasma testosterone in men: relation to gonadotropins and prolactin.
J Clin Endocrinol Metab. 1975 Jun;40(6):1027-33. doi: 10.1210/jcem-40-6-1027.
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