易患高血压和抗高血压大鼠延髓和下丘脑环磷酸腺苷的生成

Cyclic AMP generation in medulla oblongata and hypothalamus of hypertension-prone and -resistant rats.

作者信息

Kobrin I, Ebstein R, Belmaker R, Ben-Ishay D

出版信息

J Neurochem. 1981 Mar;36(3):1285-8. doi: 10.1111/j.1471-4159.1981.tb01730.x.

DOI:10.1111/j.1471-4159.1981.tb01730.x

Abstract

Accumulation of cAMP induced by noradrenaline (NA) was higher in the medulla oblongata (MO) of hypertension-prone (H) than in resistant (N) rats, 113 +/- 3 vs. 72 +/- 4 (p less than 0.01). In the hypothalamus (HYP) it was higher in N than in H rats, 148 +/- 8 vs. 92 +/- 6 (p less than 0.01). In both anterior and posterior HYP, the accumulation of cAMP was significantly higher in N than in H rats. cAMP accumulation, in the presence of increasing concentrations of phosphodiesterase inhibitor, showed significant strain differences in both MO and HYP. The observed strain differences in cAMP may be pertinent to the disparate susceptibility to hypertension of H and N rats.

摘要

去甲肾上腺素（NA）诱导的环磷酸腺苷（cAMP）在高血压易感（H）大鼠延髓（MO）中的积累高于抗性（N）大鼠，分别为113±3和72±4（p<0.01）。在下丘脑（HYP）中，N大鼠的cAMP积累高于H大鼠，分别为148±8和92±6（p<0.01）。在HYP的前部和后部，N大鼠的cAMP积累均显著高于H大鼠。在磷酸二酯酶抑制剂浓度增加的情况下，cAMP积累在MO和HYP中均表现出显著的品系差异。观察到的cAMP品系差异可能与H和N大鼠对高血压的不同易感性有关。