胍乙啶、6-羟基多巴胺和二乙基二硫代氨基甲酸盐对被动回避记忆保持影响的比较。

Comparisons of the effects of guanethidine, 6-hydroxydopamine and diethyldithiocarbamate on retention of passive avoidance.

作者信息

Palfai T, Walsh T J

出版信息

Pharmacol Biochem Behav. 1980 Dec;13(6):805-9. doi: 10.1016/0091-3057(80)90211-7.

Abstract

Depending on the dose levels, guanethidine and diethyldithiocarbamate produced time dependent amnesia for a one-trial passive avoidance task. 6-Hydroxydopamine given at any dose level or at any time interval before or after training did not result in retention deficits. The results were discussed in terms of the effects of these agents on peripheral biogenic amines and the possible role of these amines in memory formation.

摘要

根据剂量水平，胍乙啶和二乙基二硫代氨基甲酸盐对一次性被动回避任务产生了时间依赖性遗忘。在训练前或训练后的任何剂量水平或任何时间间隔给予6-羟基多巴胺均未导致记忆保持缺陷。根据这些药物对外周生物胺的影响以及这些胺在记忆形成中的可能作用对结果进行了讨论。