Haycock J W, van Buskirk R, McGaugh J L
Pharmacol Biochem Behav. 1976 Nov;5(5):525-8. doi: 10.1016/0091-3057(76)90263-x.
These experiments examined the effects in mice of posttraining injections of diethyldithiocarbamate (DDC) upon retention (7 days after training) of active avoidance learning and upon whole brain catecholamine levels. When administered immediately following training, DDC enhanced retention performance. The degree of enhancement varied directly with dose. DDC did not significantly affect retention performance if the injections were delayed 1 or 4 hours after training. Also, DDC administered 30 min prior to training did not affect retention performance. DDC (900 mg/kg) produced a large but transient increase in whole brain dopamine (DA) levels while norepinephrine (NE) levels were lowered.
这些实验研究了训练后注射二乙基二硫代氨基甲酸盐（DDC）对小鼠主动回避学习记忆保持（训练后7天）以及全脑儿茶酚胺水平的影响。训练后立即注射DDC可增强记忆保持表现。增强程度与剂量成正比。如果在训练后延迟1或4小时注射，DDC对记忆保持表现无显著影响。此外，训练前30分钟注射DDC也不影响记忆保持表现。DDC（900毫克/千克）可使全脑多巴胺（DA）水平大幅但短暂升高，而去甲肾上腺素（NE）水平则降低。
