Barker J L, Mathers D A
Science. 1981 Apr 17;212(4492):358-61. doi: 10.1126/science.6259733.
Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.
利用在培养中生长的小鼠脊髓神经元进行电压钳记录，以研究12种结构与γ-氨基丁酸（GABA）相似的物质所诱导的膜电流波动。波动分析提供了这些反应背后基本事件电特性的估计值。除甘氨酸外，所有物质激活通道的平均电导估计值与GABA的估计值无显著差异，而激动剂激活通道的平均持续时间均与GABA的显著不同。结果表明，除甘氨酸外，所有测试物质均激活电导相似但持续时间不同的通道。
