Collin C, Devane W A, Dahl D, Lee C J, Axelrod J, Alkon D L
Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10167-71. doi: 10.1073/pnas.92.22.10167.
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic excitation]: transformation of GABA-mediated synaptic inhibition into synaptic excitation. This transformation persists with no further paired stimulation for 60 min or longer and is termed long-term transformation. Long-term transformation is shown to contribute to pairing-induced long-term potentiation but not to long-term potentiation induced by presynaptic stimulation alone. Further support for such mechanistic divergence is provided by pharmacologic effects on long-term transformation as well as these two forms of long-term potentiation by Cl- channel blockers, glutamate and GABA antagonists, as well as the endogenous cannabinoid ligand anandamide.
有证据表明存在一种独特类型的海马体突触修饰[先前在软体动物γ-氨基丁酸（GABA）突触中，在突触前和突触后配对兴奋后有过描述]：GABA介导的突触抑制转变为突触兴奋。这种转变在没有进一步配对刺激的情况下持续60分钟或更长时间，被称为长期转变。长期转变被证明有助于配对诱导的长期增强，但对仅由突触前刺激诱导的长期增强没有作用。氯离子通道阻滞剂、谷氨酸和GABA拮抗剂以及内源性大麻素配体花生四烯酸乙醇胺对长期转变以及这两种形式的长期增强的药理作用，为这种机制差异提供了进一步支持。
