Poisson M, Pouillart P, Bataini J P, Hauw J J, Pertuiset B F
Sem Hop. 1981;57(5-6):229-35.
The authors present the therapeutical results of two clinical and histological homogeneous series of malignant gliomas. The first group includes 46 patients operated upon and treated successively by chemotherapy associating VM26 and CCNU, a conventional delayed radiotherapy 6 months after surgery and again chemotherapy. In this group, the mean survival is 17 months and 46% of patients were surviving at 18 months. The second group includes 28 patients operated upon and treated with the same associated chemotherapy without radiation therapy. The mean survival was 11 months and 24% of patients were surviving at 18 months. The comparison of results shows that after surgery, the association of a chemotherapy and delayed radiotherapy is more efficient than chemotherapy alone. However, the systematic study of nervous system tolerance to irradiation post-chemotherapy suggests that, in some cases, the chemotherapy is able of increasing the pathogenic effect of irradiation on the brain.
作者展示了两组临床和组织学特征均一的恶性胶质瘤的治疗结果。第一组包括46例接受手术治疗的患者，随后依次接受联合VM26和CCNU的化疗、术后6个月常规延迟放疗以及再次化疗。在该组中，平均生存期为17个月，46%的患者在18个月时仍存活。第二组包括28例接受手术治疗的患者，接受相同的联合化疗但未接受放疗。平均生存期为11个月，24%的患者在18个月时仍存活。结果比较显示，术后化疗与延迟放疗联合比单纯化疗更有效。然而，对化疗后神经系统对放疗耐受性的系统研究表明，在某些情况下，化疗能够增加放疗对大脑的致病作用。
