Chatel M, Dresse D, Huguenin P, Loubrieux G, Menault F, Poisson M
Sem Hop. 1981;57(5-6):225-8.
The results of a multicentric study of three combined therapeutic protocols for malignant gliomas are reported. The goal was the evaluation of "Delayed" versus "Immediate" Radiotherapy. All patients were operated on, the radiotherapy was 5 800 rad. whole brain. The drugs used were : Day 1 - Day 2 Epipodophylotoxine 60 mg/m2/day. Day 3 - Day 4 CCNU 60 mg/m2/day. The mean survival times were : "total" surgery versus "partial" surgery: "total" group : 52 cases - mean survival : 44 weeks ; "partial" group : 60 cases - mean survival : 48 weeks : 1) protocol A : surgery + chemotherapy alone : 60 patients/34 weeks ; 2) protocol B : surgery + radiotherapy + chemotherapy :22 patients/43 weeks ; 3) protocol C : surgery + chemotherapy 4 cycles + radiotherapy + chemotherapy : 51 patients/71 weeks. The percentage of survivors at 12 months was Prot. A : 57% - Prot. B : 32% - Prot. C : 70%. These results are in favor of "Delayed" radiotherapy. They are statistically significant, and prompt us to pursue such a trial for getting confirmation upon numerically broader groups of patients.
本文报告了一项针对恶性胶质瘤的三种联合治疗方案的多中心研究结果。目的是评估“延迟”放疗与“即刻”放疗。所有患者均接受了手术，放疗剂量为全脑5800拉德。使用的药物为：第1天至第2天，表鬼臼毒素60mg/m²/天；第3天至第4天，洛莫司汀60mg/m²/天。平均生存时间为：“全切”手术与“部分切除”手术相比：“全切”组52例，平均生存时间44周；“部分切除”组60例，平均生存时间48周。1）方案A：单纯手术+化疗，60例患者，生存34周；2）方案B：手术+放疗+化疗，22例患者，生存43周；3）方案C：手术+4周期化疗+放疗+化疗，51例患者，生存71周。12个月时的生存率为：方案A：57%；方案B：32%；方案C：70%。这些结果支持“延迟”放疗。结果具有统计学意义，促使我们开展此类试验，以便在更多患者群体中得到证实。
