Kellerer K, Grubbauer H M
Wien Klin Wochenschr. 1978 Jan 6;90(1):13-6.
An unselected, mycologically-controlled trial was conducted at the University Children's Hospital of Graz on the treatment of nappy rash by the topical application of Canesten (clotrimazole), a broad-spectrum mycotic in the form of a 1% cream. 56 children, ranging in age from 3 weeks to 41/2 years, were treated for thrush, principally located in the genital area. Only some of the children were admitted primarily on account of the oral and/or perianal moniliasis. The majority of the children were hospitalized for some other reason and thrush was diagnosed as an accompanying condition. Candida albicans proved to be the most frequent pathogenic organism. The results of therapy were judged according to mycological and clinical criteria. The mycological findings became negative in 54 out of the 56 children. Clinical improvement was apparent in all cases between the 5th and 10th day of therapy; complete recovery occurred between the 5th and 25th day, depending on the extent and localization of the moniliasis. One child showed improvement in, but not recovery from the disease, because therapy was interrupted on premature discharge from hospital. Therapy was unsuccessful in the remaining child, although slight improvement occurred. Tolerance was good in all patients on application of Canesten cream thrice daily.
在格拉茨大学儿童医院进行了一项未经筛选、有真菌学对照的试验，以研究外用凯妮汀（克霉唑）（一种1%乳膏剂型的广谱抗真菌药）治疗尿布疹的效果。56名年龄在3周至4岁半的儿童因鹅口疮接受治疗，主要位于生殖器区域。只有部分儿童最初是因口腔和/或肛周念珠菌病入院。大多数儿童因其他原因住院，鹅口疮被诊断为伴随病症。白色念珠菌被证明是最常见的致病微生物。根据真菌学和临床标准对治疗结果进行判断。56名儿童中有54名真菌学检查结果转为阴性。治疗第5天至第10天所有病例均有明显临床改善；完全康复发生在第5天至第25天之间，取决于念珠菌病的范围和部位。一名儿童病情有所改善但未康复，因为因过早出院治疗中断。其余一名儿童治疗未成功，尽管有轻微改善。所有患者每日三次使用凯妮汀乳膏时耐受性良好。
