Sitka U, Weingärtner L
Med Klin. 1976 Apr 9;71(15):635-9.
The early infancy is especially affected by moniliasis in pediatrics. The causes are: broad spread of Candida albicans in the environment of these children, a growing immunity, the immaturity of the skin and an insufficient candida-static activity of the serum. The prematures and the newborns with an irregular birth are especially endangered. This danger is increased by simultaneous antibiotic therapy. The arising mycosis can reach from the relative harmless mouth- and diaper-thrush to serious septic diseases. An effective therapy therefore is very much desired. As new efficacious medicaments the derivates of imidazol, Clotrimazol, have proved satisfactory for the treatment of mycoses. It is as Canesten marketed. The drug possesses a strong activity against numerous fungi, some protozoa, and bacteria. In this paper it is reported on own pharmacokinetic and therapeutic investigations with Clotrimazol. The substance has been very useful for the treatment of mouth- and diaper-thrush. Clotrimazol was administered as BAYb 5097 peroral and local as Canesten -solution 1% and -cream 1%. There were 171 treatments carried out. Essential side-effects were not observed.
在儿科学中，婴儿早期尤其易受念珠菌病影响。病因如下：白色念珠菌在这些儿童所处环境中广泛传播、免疫力不断增强、皮肤不成熟以及血清抗念珠菌活性不足。早产儿和出生情况异常的新生儿尤其危险。同时进行抗生素治疗会增加这种危险。引发的真菌病范围可从相对无害的鹅口疮和尿布疹到严重的败血症。因此，非常需要一种有效的治疗方法。作为新型有效药物，咪唑衍生物克霉唑已被证明对真菌病治疗效果令人满意。它以凯妮汀品牌销售。该药物对多种真菌、一些原生动物和细菌具有强大活性。本文报道了关于克霉唑自身的药代动力学和治疗研究。该物质对治疗鹅口疮和尿布疹非常有效。克霉唑以BAYb 5097口服给药，以1%的凯妮汀溶液和1%的乳膏局部给药。共进行了171次治疗。未观察到严重副作用。
