钾离子（K+）与胃壁细胞及胃ATP酶的相互作用。

The interaction of K+ with gastric parietal cells and gastric ATPase.

作者信息

Sachs G, Berglindh T, Rabon E, Wallmark B, Barcellona M L, Stewart H B, Saccomani G

出版信息

Ann N Y Acad Sci. 1980;358:118-37. doi: 10.1111/j.1749-6632.1980.tb15391.x.

DOI:10.1111/j.1749-6632.1980.tb15391.x

Abstract

The gastric H+ secretion in isolated cell requires K+ and is ATP dependent. There is also evidence in the cell system for Na+ inhibition of H+ secretion. The isolated gastric ATPase also shows K+ activation and inhibition by K+ or Na+ located on the ATP binding side of the enzyme, which corresponds to the cytoplasmic face of the enzyme. Gastric vesicles are activated in terms of transport activity by internal K+, and this site, inhibited by reagents that modify carboxyl groups, is required for enzyme turnover and transport.

摘要

离体细胞中的胃H⁺分泌需要K⁺且依赖ATP。在细胞系统中也有证据表明Na⁺可抑制H⁺分泌。离体胃ATP酶也表现出K⁺激活以及位于酶的ATP结合侧（对应于酶的细胞质面）的K⁺或Na⁺抑制作用。胃小泡的转运活性可被内部K⁺激活，该位点被修饰羧基的试剂抑制，是酶周转和转运所必需的。