The fate of [103Ru]ruthenocene in mice and rats.

1. The metabolic fate, rate of excretion and organ distribution of [103Ru]ruthenocene, administered to mice intravenously, intraperitoneally and orally, were investigated. 2. Most of the 103Ru was eliminated from the body in 24 h; the remainder was located mostly in liver, gastro-intestinal tract and fat and was slowly excreted. 3. The 103Ru was excreted in the bile and urine as ruthenocene-O-glucuronide, as shown by enzymic hydrolysis and mass spectrum of the permethylated metabolite.